Recent Publications
2023
2022
Poirier A, Tremblay ML. Pharmacological potentiation of monocyte-derived dendritic cell cancer immunotherapy. Cancer Immunol Immunother. 2022 Nov 28. doi: 10.1007/s00262-022-03333-y. Epub ahead of print. PMID: 36441193.
Vinette V, Aubry I, Insull H, Uetani N, Hardy S, Tremblay ML. Protein tyrosine phosphatome metabolic screen identifies TC-PTP as a positive regulator of cancer cell bioenergetics and mitochondrial dynamics. FASEB J. 2021 Jul;35(7):e21708. doi: 10.1096/fj.202100207R. PMID: 34169549.
2021
Zolotarov Y, Ma C, González-Recio I, Hardy S, Franken GAC, Uetani N, Latta F, Kostantin E, Boulais J, Thibault MP, Côté JF, Díaz-Moreno I, Quintana AD, Hoenderop JGJ, Martínez-Cruz LA, Tremblay ML, de Baaij JHF. ARL15 modulates magnesium homeostasis through N-glycosylation of CNNMs. Cell Mol Life Sci. 2021 Jul;78(13):5427-5445. doi: 10.1007/s00018-021-03832-8. Epub 2021 Jun 5. PMID: 34089346; PMCID: PMC8257531.
Vinette V, Aubry I, Insull H, Uetani N, Hardy S, Tremblay ML. Protein tyrosine phosphatome metabolic screen identifies TC-PTP as a positive regulator of cancer cell bioenergetics and mitochondrial dynamics. FASEB J. 2021 Jul;35(7):e21708. doi: 10.1096/fj.202100207R. PMID: 34169549.
2020
Chouleur T, Tremblay ML, Bikfalvi A. Mechanisms of invasion in glioblastoma. Curr Opin Oncol. 2020 Nov;32(6):631-639. doi: 10.1097/CCO.0000000000000679. PMID: 32852310.
Poulet M, Sirois J, Boyé K, Uetani N, Hardy S, Daubon T, Dubrac A, Tremblay ML, Bikfalvi A. PRL-2 phosphatase is required for vascular morphogenesis and angiogenic signaling. Commun Biol. 2020 Oct 23;3(1):603. doi: 10.1038/s42003-020-01343-z. PMID: 33097786; PMCID: PMC7584612.
For a more exhaustive list of publications
Hardy S, Kostantin E, Wang SJ, Hristova T, Galicia-Vázquez G, Baranov PV, Pelletier J, Tremblay ML. Magnesium-sensitive upstream ORF controls PRL phosphatase expression to mediate energy metabolism. Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):2925-2934. doi: 10.1073/pnas.1815361116. Epub 2019 Feb 4. PMID: 30718434; PMCID: PMC6386685.
2019
Kostantin, E., Zolotarov, Y., Tremblay, M.L. (2019). Role of Protein Tyrosine Phosphatases in Cancer Signaling. In: Badve, S., Kumar, G. (eds) Predictive Biomarkers in Oncology. Springer, Cham. https://doi.org/10.1007/978-3-319-95228-4_30
2018
Hardy S, Kostantin E, Hatzihristidis T, Zolotarov Y, Uetani N, Tremblay ML. Physiological and oncogenic roles of the PRL phosphatases. FEBS J. 2018 Nov;285(21):3886-3908. doi: 10.1111/febs.14503. Epub 2018 May 27. PMID: 29770564.
Pike KA, Tremblay ML. Protein Tyrosine Phosphatases: Regulators of CD4 T Cells in Inflammatory Bowel Disease. Front Immunol. 2018 Oct 31;9:2504. doi: 10.3389/fimmu.2018.02504. PMID: 30429852; PMCID: PMC6220082.
Bussières-Marmen S, Vinette V, Gungabeesoon J, Aubry I, Pérez-Quintero LA, Tremblay ML. Loss of T-cell protein tyrosine phosphatase in the intestinal epithelium promotes local inflammation by increasing colonic stem cell proliferation. Cell Mol Immunol. 2018 Apr;15(4):367-376. doi: 10.1038/cmi.2016.72. Epub 2017 Mar 13. PMID: 28287113; PMCID: PMC6052838.
Pike KA, Hatzihristidis T, Bussières-Marmen S, Robert F, Desai N, Miranda-Saavedra D, Pelletier J, Tremblay ML. TC-PTP regulates the IL-7 transcriptional response during murine early T cell development. Sci Rep. 2017 Oct 16;7(1):13275. doi: 10.1038/s41598-017-13673-w. PMID: 29038451; PMCID: PMC5643372.
Uetani N, Hardy S, Gravel SP, Kiessling S, Pietrobon A, Wong NN, Chénard V, Cermakian N, St-Pierre J, Tremblay ML. PRL2 links magnesium flux and sex-dependent circadian metabolic rhythms. JCI Insight. 2017 Jul 6;2(13):e91722. doi: 10.1172/jci.insight.91722. PMID: 28679948; PMCID: PMC5499375.
2017
Tiffanie Chouleur, Andrea Emanuelli, Wilfried Souleyreau, Marie-Alix Derieppe, Teo Leboucq, Serge Hardy, Thomas Mathivet, Michel L. Tremblay, Andreas Bikfalvi; PTP4A2 Promotes Glioblastoma Progression and Macrophage Polarization Under Microenvironmental Pressure. Cancer Research Communications (2024)
Hardy S, Zolotarov Y, Coleman J, Roitman S, Khursheed H, Aubry I, et al. PRL-1/2 phosphatases control TRPM7 magnesium-dependent function to regulate cellular bioenergetics. Proceedings of the National Academy of Sciences. 2023;120(14):e2221083120.
Poirier, A., Wu, C., Hincapie, A.M. et al. TAOK3 limits age-associated inflammation by negatively modulating macrophage differentiation and their production of TNFα. Immunity & Ageing (2023)
Penafuerte C, Feldhammer M, Mills JR, Vinette V, Pike KA, Hall A, Migon E, Karsenty G, Pelletier J, Zogopoulos G, Tremblay ML. Downregulation of PTP1B and TC-PTP phosphatases potentiate dendritic cell-based immunotherapy through IL-12/IFNγ signaling. Oncoimmunology. 2017 Apr 28;6(6):e1321185. doi: 10.1080/2162402X.2017.1321185. PMID: 28680757; PMCID: PMC5486178.
Wu CL, Hardy S, Aubry I, Landry M, Haggarty A, Saragovi HU, Tremblay ML. Identification of function-regulating antibodies targeting the receptor protein tyrosine phosphatase sigma ectodomain. PLoS One. 2017 May 30;12(5):e0178489. doi: 10.1371/journal.pone.0178489. PMID: 28558026; PMCID: PMC5449173.
Penafuerte C, Perez-Quintero LA, Vinette V, Hatzihristidis T, Tremblay ML. Mining the Complex Family of Protein Tyrosine Phosphatases for Checkpoint Regulators in Immunity. Curr Top Microbiol Immunol. 2017;410:191-214. doi: 10.1007/82_2017_68. PMID: 28929190.
2024
Poirier, A., Picard, C., Labonté, A. et al. PTPRS is a novel marker for early Tau pathology and synaptic integrity in Alzheimer’s disease. Sci Rep 14, 14718 (2024). https://doi.org/10.1038/s41598-024-65104-2
Poirier, A., et al. The induction of SHP-1 degradation by TAOK3 ensures the responsiveness of T cells to TCR stimulation. Science Signaling .17,eadg4422(2024).